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KMID : 1007020080060010038
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Korean Soceity of Osteroporosis
2008 Volume.6 No. 1 p.38 ~ p.42
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Effect of Cyclin Therapy of Combined Tibolone, Calcitonin and Calcium on the Bone Mineral Density in Postmenopausal Women
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Eo Wan-Kyu
Jung Hyuk
Kim Heung-Yeol
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Abstract
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Objectives: Our study was designed to analyze the synergic effect after 2 times combined periodic therapy of tibolone, synthetic nasal spray type salmon calcitonin and calcium for 3 months each.
Methods: This study was based on 101 patients among 269 patients treated osteoporotic drug(combination therapy of tibolone, synthetic salmon calcitonin, calcium agent) from January 2007 to October 2007, with a minimum follow up of 1 year. We compared initial bone mineral density(BMD) with post-treatment BMD and laboratory finding (ionized calcium, phosphate, alkaline phosphatase in serum and calcium/creatinine ratio in urine) which were statistically analyzed.
Results: BMD was increased in spine(0.63g/cm² to 0.66g/cm²) and not increased in hip(femur neck: 0.61g/cm² to 0.61g/cm², trochanter: 0.56g/cm² to 0.49g/cm², Ward\’s triangle: 0.38g/cm² to 0.39g/cm²), but was not statistically significant(P>0.05). The laboratory finding was tendency of decreased bone metabolism(ionized calcium: 9.7mg/dL to 9.4mg/dL, phosphate: 4.3mg/dL to 3.8mg/dL, ALP: 100.0IU/L to 83.1IU/L in serum and calcium/creatinine ratio in urine: 11.0 to 9.2), but was not statistically significant(P>0.05).
Conclusion: In the osteoporotic post-menopausal women, the periodic combined therapy of tibolone, calcitonin and oral calcium agent did not show the synergic effect in BMD and bone metabolism. This periodic combined therapy does not recommendable to osteoporotic post-menopausal women.
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KEYWORD
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Osteoporosis, Tibolone, Calcitonin, Bone mineral density, bone metabolism
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